منابع مشابه
Chiral Separations: Liquid Chromatography
The use of CE in the analysis of pharmaceuticals is now becoming Rrmly established as a useful complement and alternative to the more widely employed technique of HPLC. The major attractions of CE are that considerable cost and time savings are possible, especially in the areas of chiral analysis and in the determination of solutes having limited or no chromophore. The recent advent of the use ...
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The engineering considerations common to large scale chromatographic purification of proteins are reviewed. A discussion of the industrial chromatography fundamentals is followed by aspects which affect the scale of separation. The separation column geometry, the effect of the main operational parameters on separation performance, and the physical characteristics of column packing are treated. ...
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The use of polyethylene glycols (PEG) is widespread in the pharmaceutical industry as a method to improve the pharmacokinetic qualities of protein and peptide therapeutics. However, such modifications also increase the heterogeneity of protein structures and generate difficulties in purifying such modified species away from the native protein. As PEGylation exhibits the majority of its effect o...
متن کاملA Novel Chromatography Format for High Efficiency Separations
SEPARATIONS W. De Malsche*, J. Op De Beeck, Selm De Bruyne, H. Gardeniers and Gert Desmet Vrije Universiteit Brussel, BELGIUM and Mesa+ Institute for Nanotechnology, THE NETHERLANDS ABSTRACT A non-porous C8 coated silicon pillar channel design is presented that allows the achievement of a high pressure and high efficiency operation for HPLC separations. Performing on-chip injection and detectio...
متن کاملOptimizing separations in online comprehensive two‐dimensional liquid chromatography
Online comprehensive two-dimensional liquid chromatography has become an attractive option for the analysis of complex nonvolatile samples found in various fields (e.g. environmental studies, food, life, and polymer sciences). Two-dimensional liquid chromatography complements the highly popular hyphenated systems that combine liquid chromatography with mass spectrometry. Two-dimensional liquid ...
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ژورنال
عنوان ژورنال: Annals of Chromatography and Separation Techniques
سال: 2015
ISSN: 2473-0696
DOI: 10.36876/acst.1011